Hiroshi Sugiyama Selected Research

imidazole

1/2021	Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition.
1/2021	Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment.
12/2020	Design, synthesis and anti-cancer activity of pyrrole-imidazole polyamides through target-downregulation of c-kit gene expression.
1/2020	Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole-imidazole polyamide.
6/2017	Genetic regulation of the RUNX transcription factor family has antitumor effects.
1/2016	Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.
1/2015	Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
3/2010	Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide.
1/2006	Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element.

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Hiroshi Sugiyama Research Topics

Disease

46	Neoplasms (Cancer) 10/2022 - 02/2003
6	Parkinson Disease (Parkinson's Disease) 12/2018 - 01/2014
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 06/2017
4	Renal Cell Carcinoma (Grawitz Tumor) 07/2022 - 01/2006
3	Carcinogenesis 07/2022 - 05/2007
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 01/2018
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2015
3	Breast Neoplasms (Breast Cancer) 01/2020 - 10/2014
3	Carcinoma (Carcinomatosis) 01/2007 - 01/2005
2	Ascites 06/2021 - 01/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 12/2018
2	Immune System Diseases (Immune Disorders) 01/2021 - 12/2018
2	Adenocarcinoma 01/2020 - 03/2010
2	Neoplasm Metastasis (Metastasis) 01/2020 - 03/2010
2	Churg-Strauss Syndrome (Allergic Angiitis) 01/2019 - 06/2011
2	Inflammation (Inflammations) 01/2019 - 01/2015
2	Leukemia 11/2017 - 06/2017
2	Autoimmune Diseases (Autoimmune Disease) 01/2016 - 01/2012
2	Hyperplasia 03/2009 - 07/2008
1	Medulloblastoma 10/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2022
1	Neuroinflammatory Diseases 01/2021
1	Ataxia (Dyssynergia) 01/2021
1	Tremor (Tremors) 01/2021
1	Hypersensitivity (Allergy) 01/2021
1	MELAS Syndrome (Syndrome, MELAS) 01/2021
1	Rhabdoid Tumor (Rhabdoid Tumors) 01/2021
1	Fragile X Tremor Ataxia Syndrome 01/2021
1	Avulsion Fractures 12/2020
1	Lymphoma (Lymphomas) 11/2020
1	Osteosarcoma (Osteogenic Sarcoma) 01/2020
1	Cognitive Dysfunction 12/2018
1	Psychotic Disorders (Schizoaffective Disorder) 12/2018
1	Apraxias (Dyspraxia) 01/2018
1	Intellectual Disability (Idiocy) 01/2018
1	Osteoarthritis 01/2018
1	ATR-X syndrome 01/2018
1	alpha-Thalassemia 01/2018

Drug/Important Bio-Agent (IBA)

25	Nylons (Nylon)IBA 10/2022 - 01/2005
12	Proteins (Proteins, Gene)FDA Link 07/2022 - 02/2003
12	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 03/2004
9	PyrrolesIBA 01/2021 - 01/2006
9	imidazoleIBA 01/2021 - 01/2006
8	Alkylating AgentsIBA 02/2022 - 12/2006
7	EnzymesIBA 12/2018 - 02/2003
5	Transcription Factors (Transcription Factor)IBA 11/2020 - 10/2014
5	Messenger RNA (mRNA)IBA 01/2020 - 07/2008
4	Chlorambucil (Leukeran)FDA Link 10/2022 - 01/2018
3	Core Binding Factor Alpha 2 SubunitIBA 01/2021 - 06/2017
3	C-Reactive ProteinIBA 01/2015 - 01/2014
2	Indicators and Reagents (Reagents)IBA 07/2022 - 02/2022
2	Mitochondrial DNA (mtDNA)IBA 01/2022 - 01/2021
2	Amyloid (Amyloid Fibrils)IBA 01/2021 - 12/2019
2	GuanineIBA 01/2021 - 01/2019
2	Biological ProductsIBA 12/2020 - 01/2019
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2020 - 01/2013
2	MicroRNAs (MicroRNA)IBA 06/2020 - 10/2017
2	LigandsIBA 01/2019 - 08/2011
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2019 - 08/2011
2	RNA (Ribonucleic Acid)IBA 01/2016 - 08/2014
2	Codon (Codons)IBA 01/2016 - 10/2015
2	Adenine FDA LinkGeneric 04/2015 - 02/2010
2	Biomarkers (Surrogate Marker)IBA 01/2015 - 01/2015
2	Levodopa (L Dopa)FDA LinkGeneric 01/2015 - 01/2014
2	Bleomycin (Blenoxane)FDA LinkGeneric 03/2006 - 06/2003
2	Cisplatin (Platino)FDA LinkGeneric 03/2006 - 06/2003
1	Etoposide (VP 16)FDA LinkGeneric 07/2022
1	Tyrosine Kinase InhibitorsIBA 02/2022
1	Designer DrugsIBA 01/2022
1	Programmed Cell Death 1 ReceptorIBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 09/2021
1	Amino Acids FDA Link 09/2021
1	Blood Proteins (Serum Proteins)IBA 06/2021
1	Antineoplastic Agents (Antineoplastics)IBA 06/2021
1	AlbuminsIBA 06/2021
1	AcidsIBA 01/2021
1	Caspase 3 (Caspase-3)IBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	protoporphyrin IXIBA 01/2021
1	CytosineIBA 01/2021
1	OligodeoxyribonucleotidesIBA 01/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021
1	Phosphates (Orthophosphate)IBA 01/2021
1	CPG-oligonucleotideIBA 01/2021
1	B-Form DNA (B-DNA)IBA 12/2020
1	sphingosine kinaseIBA 11/2020
1	SOXB1 Transcription FactorsIBA 01/2020
1	Nucleic AcidsIBA 01/2019
1	SteroidsIBA 01/2019
1	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2018
1	ApolipoproteinsIBA 12/2018
1	Donepezil (Aricept)FDA LinkGeneric 12/2018
1	Proteoglycans (Proteoglycan)IBA 01/2018
1	Proanthocyanidins (Procyanidins)IBA 01/2018
1	benoxinate (oxybuprocaine)FDA Link 01/2018

Therapy/Procedure

12	Therapeutics 01/2022 - 11/2007
6	Drug Therapy (Chemotherapy) 06/2021 - 01/2007
5	Immunotherapy 01/2022 - 01/2012
1	Conservative Treatment 12/2020